Osteocalcin, activated by vitamin K2, is a protein hormone in the dentin of bones and teeth.
It is formed in osteoblasts and regulates calcium metabolism.
The effects of taking Vitamin K2
※This data is a numerical data of the average cOC/ucOC concentration (ng/ml) in serum
cOC=Activated osteocalcin (The higher the cOC concentration in the body, the better calcium metabolism can be)
ucOC= Inactivated osteocalcin (The higher the concentration, the more inactivated osteocalcin in the body, which requires taking MK-7)
coC/ucOC=Activated osteocalcin/Deactivated osteocalcin ratio (The higher the cOC/ucOC value, the better the calcium metabolism can be)
*Low-Dose Daily Intake of Vitamin K-2 (Menaquinone-7) Improves Osteocalcin gamma-Carboxylation: A Double-Blind, Randomized Controlled Trials, Journal of Nutritional Science and Vitaminology. December 2015, Naoko Inaba, Toshiro Sato and Takatoshi Yamashita
“Comparison of the effects of vitamin K between men and women in Study 2. Percentage changes in carboxylated osteocalcin (cOC) (A), in undercarboxylated osteocalcin (ucOC) (B) and cOC/ucOC ratio (C). Data are mean6SD. ○: Placebo, ●: MK-7. * p,0.05, ** p,0.01 vs. placebo (Wilcoxon rank-sum test). † p,0.05, †† p,0.01 vs. baseline (Wilcoxon signed-rank test). n523 for men and n534 for women in the placebo group, and n523 (day 0, 28, 56 and 112) or n522 (day 84) for men and n535 for women in the MK-7 group.”
As a result of a 2014 clinical trial of MK-7 intake in menopausal women in Korea, when postmenopausal women consumed MK-7, significant data confirmed the presence of Bone specific ALP and osteocalcin, which are indicators of bone density and bone formation*.
* Effect of Vitamin K2 (Menaquinone-7) in Cheongukjang Powder on Bone Health Circulation in Postmenopausal Women, Seon-Ok Bang, Kum-Suk Kim and Min-Hong Jeong, Korean J. Food Nutr. Vol. 29. No. 6, 978~984 (2016)
As such, it can help improve and prevent osteoporosis by increasing bone density through intake of vitamin K2, improving bone health, and helping bone metabolism.
When osteocalcin is activated by vitamin K2 in teeth, new dentin grows on the teeth, and as new dentin grows, tooth decay is reduced. As with bones, taking vitamin K2 can help strengthen teeth and reduce the rate of tooth loss due to aging.
Promotes bone growth in
children and adolescents
Bone growth is most actively developed in childhood and adolescence, and by the age of 18-20, it forms up to 80-90% of peak bone mass. An adequate supply of vitamin K2 to children and adolescents at this time is essential for healthy and strong bone growth.
The need for osteocalcin, a vitamin K2-dependent protein, is 8 to 10 times higher in children than in adults, indicating that vitamin K2 is a very important vitamin for the growth of children and adolescents. However, as the consumption of processed foods and foods rich in vitamin K2 have been significantly reduced, most children are experiencing vitamin K2 deficiency. Therefore, taking vitamin K2 is essential for the development of bone mass and the prevention of bone health for children.